This paper discusses the debate over whether emotional expressions are spontaneous or intentional actions. We describe a variety of empirical evidence supporting these two possibilities. But we argue that the spontaneous-intentional distinction fails to explain the psychological dynamics of emotional expressions. We claim that a complex systems perspective on intentions, as self-organized critical states, may yield a unified view of emotional expressions as a consequence of situated action. This account simultaneously acknowledges the embodied status of environment, evolution, culture and mind (...) in theories of emotion. (shrink)

The current debate on “free agency” seems to highlight the romantic aspects of free agent and considers it a genuine response to changing economic conditions (e.g., high-unemployment rate, importance of knowledge in the labor market, the eclipse of organizational loyalty, and self pride). Little attention, if any, has been given to the religious root of the free agency concept and its persistent existence across history. In this paper, the current discourse on free agency and the conditions that have led to (...) its emergence are briefly discussed. The paper focuses on the theological perspectives of Judaism, Christianity, and Islam on the concept. Implications for management and business organizations are provided. (shrink)

Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

The meaning of the once widely used term the Gibbs Free Energy in terms of available work energy is perfectly illustrated for chemical reactions by the Van’t Hoff Equilibrium Box. Combining this with DeDonder’s extent of reaction variable and using the reaction of $$\hbox {NH}_3$$ to $$\hbox {H}_2$$ and $$\hbox {N}_2$$ at $$200^{\circ }\hbox {C}$$ as an example shows the difference between total work energy and available work energy, and in addition allows calculation of the equilibrium composition, demonstration of (...) the minimum in the Gibbs energy curve, and the standard relationship between $$\Delta _\textrm{r}G^{\circ }$$ and $$\ln {K}$$. (shrink)

G. C. J. Midgley; XIV—Linguistic Rules, Proceedings of the Aristotelian Society, Volume 59, Issue 1, 1 June 1959, Pages 271–290, https://doi.org/10.1093/aristot.

According to the prevailing sentiment, changing the past is logically impossible. The prevailing sentiment is wrong. In this paper, I argue that the claim that changing the past entails a contradiction ultimately rests upon an empirical assumption, and so the conclusion that changing the past is logically impossible is to be resisted. I then present and discuss a model of time which drops the empirical assumption and coherently models changing the past. Finally, I defend the model, and changing the past, (...) against objections. (shrink)

In this paper, we explore Fregean metatheory, what Frege called the New Science. The New Science arises in the context of Frege’s debate with Hilbert over independence proofs in geometry and we begin by considering their dispute. We propose that Frege’s critique rests on his view that language is a set of propositions, each immutably equipped with a truth value (as determined by the thought it expresses), so to Frege it was inconceivable that axioms could even be considered to be (...) other than true. Because of his adherence to this view, Frege was precluded from the sort of metatheoretical considerations that were available to Hilbert; but from this, we shall argue, it does not follow that Frege was blocked from metatheory in toto. Indeed, Frege suggests in Die Grundlagen der Geometrie a metatheoretical method for establishing independence proofs in the context of the New Science. Frege had reservations about the method, however, primarily because of the apparent need to stipulate the logical terms, those terms that must be held invariant to obtain such proofs. We argue that Frege’s skepticism on this score is not warranted, by showing that within the New Science a characterization of logical truth and logical constant can be obtained by a suitable adaptation of the permutation argument Frege employs in indicating how to prove independence. This establishes a foundation for Frege’s metatheoretical method of which he himself was unsure, and allows us to obtain a clearer understanding of Frege’s conception of logic, especially in relation to contemporary conceptions. (shrink)

The Buddhist philosophy of causality is primarily a theory (naya) of the human world. Its methodology, however, is objective and critical. It rejects the weight of mere authority or tradition, relies upon experience and reason, and emphasizes the critical examination and verification of all opinions. Although the Buddhist conception of knowledge and truth has a strong empirical and pragmatic bias (cf. Nyāya‐bindu 1.1), its conception of experience does not exclude introspection, rational intuition or mystical intuition (cf. Nyāya‐bindu 1.7–11). Although its (...) conception of reason creates a logical gulf between reason and experience, the gulf is bridged by a transcendental illusion (avidyā). Its employment of reason is highly analytical and it seeks to discover the ultimate elements constituting the structures of objects and experience. The constituent elements as the locus of causation are regarded as more real than their composite structures – dharma, dhātu or kṣana as contrasted with saṅghāta or santāna. At the same time, it raises dialectical questions and seriously considers the possibility of the empirical world being merely a working illusion. It discounts the apparent stability of objects, stressing their transience, finally defined as momentariness (see, for example, Ratnakīrti's Kṣaṇa‐bhaṅgasiddhi). It rejects the category of substance for that of process. Causality is thus regarded not as a dynamic interaction between substances, but as a functional, many‐one relationship of order characterized by invariance and uniformity within any given type of process. (shrink)

A General treatment of Greek compounds seems much to be desired. It would have to be undertaken by one who had an up-to-date philological equipment, to which I cannot lay claim. But rather with the hope of eliciting discussion on the subject and learning from others I offer the following observations, and in further study of the subject should be grateful to anyone who would advise as to the exact statistics that may be desirable over and above what I give (...) below. I was led to the subject by a feeling that the treatment of many individual compounds by editors was far from satisfactory, and that possibly a collection of the material might help to bring out the exact meaning of some of the well-known difficulties in the Tragedians. One is dealing here with a highly developed and somewhat arbitrary poetic idiom, and it may perhaps be impossible, as one must admit from the outset, always to make precise the poet's meaning, but it is worth while to make the attempt. (shrink)

Exposure of man to chemical agents can occur intentionally, as in the treatment of disease, or inadvertently because the environment contains a wide range of synthetic or naturally occurring chemicals. The alkylating agents are a diverse group of compounds (Fig. 1) and comprise a good example of such xenobiotics, since much is known about their occurrence, and their biological effects include carcinogenicity, mutagenicity, toxicity and teratogenicity.Exposure to potentially carcinogenic alkylating agents such as nitrosamines may occur occupationally, from cigarette smoke, from (...) certain foodstuffs and even endogenously through the ingestion of the appropriate precursor chemicals.1 At the other extreme, the cytotoxic effects of agents such as the chloroethylating nitrosamides or mustards have been exploited in the design of certain antitumour drugs.2 The effectiveness of antitumour agents and the other, mostly adverse, biological effects of alkylating agents have been ascribed to their ability to damage cellular macromolecules, in particular DNA. This review concentrates on investigations carried out over the past two years on the role of DNA damage in carcinogenesis, but we shall see how recent advances in this area of research have also led to a better understanding of the mechanisms of the cytotoxic effects of alkylating antitumour agents. (shrink)

One popular test for distinguishing linked and convergent argument structures is Robert Yanal's Ordinary Summing Test. Douglas Walton, in his comprehensive survey of possible candidates for the linked/convergent distinction, advocates a particular version of Yanal's test. In a recent article, Alexander Tyaglo proposes to generalize and verifY Yanal's algorithm for convergent arguments, the basis for Yanal's Ordinary Summing Test. In this paper I will argue that Yanal's ordinary summing equation does not demarcate convergence and so his Ordinary Summing Test fails. (...) Hence, despite Walton's recommendation or Tyaglo's generalization, the Ordinary Summing Test should not be used for distinguishing linked argument structures from convergent argument structures. (shrink)

This is the collection of the FIRST Congress of the Italian Society for Analytic Philosophy. It is a piece of intellectual history, where we can see European Analytic Philosophers at the beginning of their renovated interest in analytic philosophy (European Society for Analytic Philosophy was founded in 1992) .